Cylindrical diffuser fibers were connected to Modulight ML6500 laser at 630 nm delivering 60-400 mW/cm irradiance and 100 J/cm2 fluence (1-fiber illumination) or 60-150 mW/cm and 540 J/cm (2-fiber illumination). In vivo experiments consisted of test subjects with murine squamous cell carcinoma tumors being treated with either a single 2 cm long cylindrical diffuser or two diffusers inside transparent catheter(s) inserted into the tumor. The aim of this study was to optimize these important light delivery parameters for H&N cancer. However, optimal light irradiance and the contribution of light-induced tissue heating to tumor response are poorly understood aspects of iPDT. It is approved in Europe for palliation of patients with advanced, refractory H&N cancer using temoporfin as a photosensitizer, while Photofrin® has been approved for other indications in USA and is being studied for H&N cancer. Interstitial photodynamic therapy (iPDT) is a promising treatment for H&N cancer where optical fibers are placed within the target tumor to deliver deep intratumoral illumination for bulky diseases. Cure rates also remain poor with irradiation or salvage surgery. Patients with refractory H&N cancer have poor prognosis, with response rates being less than 40% for chemotherapy and less than 20% for newer immunotherapies. Head & neck cancer comprises several different malignant tumors that develop in the throat, larynx, nasal cavity, sinuses, lips, or mouth. If you are interested in joining our dynamic and innovative working team in the rapidly growing field of optoelectronics, please introduce yourself to us.
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